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Nate, a 19 year old film student, and Margaret, a 52 year old spinster, are best friends in an odd, quirky, totally working kind of way... until Nate's audacious classmate Darla sets him up on a date with James. Nate's new life shakes apart his friendship with Margaret, who goes off on her own to start a career as a stand-up comedian.。该剧以“三线建设”为背景，讲述的就是上世纪六七十年代一场真实发生在西南十三省的战略大迁徙事件。该剧通过闻一达、梅湘云等三线建设者的工作生活，演绎了他们在那特殊的年代所经历的痛苦和欢乐、豪情与浪漫，讴歌了两代三线建设者献身大西北的奉献精神。。李国海为保护孟子萱免受母亲孟翠莲伤害，编织二十年谎言，却在揭示真相前罹患血癌。孟翠莲归来，伪善面目诱使孟子萱错过救治父亲时机，致其遗憾终生。最终，真相大白，孟子萱痛悔不已，孟翠莲则孤立无援，自食恶果。。